Twenty fire engines and around 125 firefighters arrived at Fowler Road in Ilford after London Fire Brigade was called about a blaze at three two-storey warehouses at 9.07pm.
Firefighters were still dealing with the blaze at around 11pm, according to an update posted by the capital’s fire service on Twitter.
Residents have been advised to keep their doors and windows shut due to smoke.
Fire crews from Romford, Dagenham, Ilford, Woodford and stations in the surrounding area have also been mobilised to tackle the fire.
London Fire Brigade does not yet know what caused the blaze.
Ilford North MP Wes Streeting thanked firefighters for their work in attempting to tackle the blaze.
Writing on Twitter, the Shadow Health Secretary said: “Huge thanks to the London Fire Brigade for their response to the fire on the Hainault industrial estate.
“I hope that no one is hurt and that everyone is safe.”
Some local residents have also shared footage of the blaze on social media.
Alongside a clip which showed plumes of smoke soaring into the London night sky, Vicki Webber said: “[There were] only about two fire engines when I went past ended up being at least 20!
“[The] fire spread quickly, [it is] so scary how fast it spread.
“Smoke is everywhere and [I] can still smell it from our house.
“Hope to God no one was hurt. Stay safe.”
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