The 79-year-old President attended a Democrat rally in New York a day before the US midterm elections. Biden gave a disordered speech to the 1,000 attendees in Yonkers on the Sarah Lawrence College lawn.
The first presidential visit to the area in 50 years saw Biden stumble on stage and appear slightly confused before returning to his speech.
Biden discussed his administration’s goal to introduce a cap on the number of prescription drugs sold to senior citizens in the US.
Biden said: “We put a cap – $2,000 a year – on prescription drugs for seniors. No matter what their cost, $2, $10, $12, $15…”
The 46th President then tripped on something which was on the floor of the stage, and he held out an arm to balance himself as he gripped the microphone with his other hand.
Members of the crowd showed their concern and laughed when he acknowledged the stumble.
The confused President looked at the point on the floor where he stumbled and said: “Oops, stepping on a – hmm- it’s black. Anyway…”
He then managed to pull himself together to continue his speech, saying: “No matter what the cost, and some cancer drugs cost as much as that, they are never going to have to pay more than $2000 [£1736].
“And we put a $35-month cap on insulin to deal with their diabetes.”
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Following the speech he spun around, seemingly looking for the way off, before pointing towards the stairs and making his way toward them.
The comment about his health comes just weeks after the President admitted that fears over his health are “legitimate”.
He said that he “could drop dead tomorrow” but noted that his current state of health is okay and that it is his “intention to run again”.
The US midterm election vote on Tuesday could spell problems for Biden as the Republicans could gain control of the House and the Senate.