NBC News, who projected the story first, announced Mr Vance will succeed Republican Rob Portman, who did not seek re-election The win keeps the state red for Republicans and has boosted the party’s chances of gaining control of the Senate, which is currently split.
Mr Vance gained national recognition for his bestselling book turned Netflix movie, Hillbilly Elegy, which detailed white poverty and addiction in Appalachia.
Originally a critic of Donald Trump, Mr Vance then changed his position and embraced the former president, and appeared with him at several rallies.
Mr Trump endorsed him early on in his primary campaign which is thought to have helped boost the Republican’s popularity.
Foreign policy analyst Nile Gardiner took to social media and said: “Big win for @jdvance1 in Ohio. This is a big blow for the Democrats.”
In their debates, both Mr Vance and Mr Ryan closed on abortion rights, border control and the January 6 Capitol riots.
The new senator Mr Vance has said he is “pro-life” but would support “some minimum national standard” for abortion restrictions.
Mr Vance also criticised the House committee currently investigating the Capitol riots as a “political hit job.”
Democrat candidate Mr Ryan accused the Republican of “running around with the election deniers, the extremists”.
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However, Mr Ryan’s appeal to conservative Ohio voters seems to have not worked, as the state has remained red the last few elections as Ohio voters came out in large numbers for Donald Trump in both his presidential campaigns.
It comes after Mr Vance appeared to be the underdog in the campaign trail as Mr Ryan received a significant funding advantage over the Republican
In the third quarter of 2022, Mr Ryan raised a sizable $17.2million, compared to Mr Vance’s $6.9million, and in the second quarter, Mr Ryan raised $9.1million to Mr Vance’s roughly $1million.