However, the tactician is likely to rotate his defensive options to hand minutes to those lacking in match fitness. Ben Davies, a regular starter last season in the back three, was an unused substitute but could replace Clement Lenglet.
Matt Doherty, who has featured for just seven minutes in two brief cameos this season, is in line for his first start of the season as first-choice wing-back Emerson Royal could be rested.
And in the centre of midfield, £25m signing Yves Bissouma is contention for his full Champions League debut after appearing from the bench against Marseille, with Pierre-Emile Hojbjerg dropping out.
Predicted Tottenham starting XI (3-4-3): Lloris; Romero, Dier, Davies; Doherty, Bentancur, Bissouma, Perisic; Richarlison, Kane, Son.